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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





This medication is used to test the function of the pituitary gland.

How To Use

This medication is best taken with milk or a snack. It is important to take this as directed to assure proper test results.

Side Effects

This medication may cause nausea, stomach upset, headache, dizziness or drowsiness. If these effects persist or become bothersome, inform your doctor. Notify your doctor if you develop: skin rash. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: pre-existing thyroid disorders, any allergies. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication appears in breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Some medications taken with Metyrapone may interact and alter test results. Tell your doctor of any over-the- counter or prescription medication you may take, especially: cyproheptadine, estrogen, phenytoin. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include fast heartbeat, severe dizziness, anxiety, confusion, weakness, vomiting, stomach pain, or diarrhea.


As part of the test to check your pituitary function, all your urine will be collected for a 24 hour period a few days before taking this medication and the day after taking this.

Missed Dose

For Cushing's disease, do not double dose if missed. Take as soon as remembered but if close to the next dose, resume regular schedule. As a diagnostic, contact your doctor.


Store at room temperature away from moisture and sunlight.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).