Find & Manage Your Patient Assistance Programs
Estimated patient savings $600,000,000.00

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Mesna is used along with ifosfamide or cyclophosphamide (anticancer medications) to protect against a bladder condition called hemorrhagic cystitis.

How To Use

This medication is administered by injection into a vein by a health care professional. It must be given along with each ifosfamide dose and at 4 and 8 hours after each ifosfamide dose. Drink at least a quart (4 cups) of liquid each day while taking this medication, unless directed otherwise by your doctor.

Side Effects

Headache, injection site reactions, flushing, dizziness, nausea, vomiting, diarrhea, bad taste in mouth, loss of appetite, drowsiness, or coughing may occur. If any of these effects persist or worsen, inform your doctor or pharmacist promptly. Tell your doctor immediately if any of these serious side effects occur: pink or red urine, fever, throat swelling, flu-like symptoms, arm or leg pain. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: other illnesses, allergies. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. A preservative (benzyl alcohol) which may be found in this product or in the liquid used to mix this product (diluent) can infrequently cause serious problems (sometimes death) if given by injection to an infant during the first months of life (neonatal period). The risk is greater with lower birth weight infants and is greater with increased amounts of benzyl alcohol. Symptoms include sudden gasping, low blood pressure, or a very slow heartbeat. Report these symptoms to the doctor immediately should they occur. If possible, a preservative-free product should be used when treating neonates. Before using this medication, tell your doctor if you are pregnant. It is not known if mesna passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor or pharmacist of all prescription and nonprescription medications you may use. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


This medication does not prevent all side effects of ifosfamide. It is useful only in protecting against hemorrhagic cystitis; however, it is not effective in all patients.

Missed Dose

It is important that each dose be used as scheduled. If you miss a dose, contact your doctor who will help establish a new dose schedule. Do not double the dose to catch up.


After preparation, this medication is stable for 24 hours at 77 degrees F (25 degrees C). Before preparation, store the vials at room temperature between 59 and 86 degrees F (15-30 degrees C).

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).