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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(ASP-er-in WITH meh-PRO-buh-mate)

COMMON BRAND NAME(S): Equagesic, Micrainin

WARNING: Children and teenagers should not use aspirin, aspirin- containing or aspirin-related medications for flu symptoms or chickenpox without first consulting a doctor. A rare but serious illness known as Reye's syndrome may occur.


This medication is a skeletal muscle relaxant in combination with aspirin, used to relieve pain and discomfort associated with musculoskeletal injuries and conditions.

How To Use

Take this with food or milk if stomach upset occurs. Take this medication with a full glass (8 oz or 240 ml) of water unless your doctor directs you otherwise. Do not lie down for at least 30 minutes after taking this drug. Use this medication exactly as prescribed. Do not increase your dose, use it more frequently or use it for a longer period of time without your doctor's approval. Also, if used for a long period of time at high doses, do not suddenly stop using this without first consulting your doctor. When used for extended periods, this medication may not work as well and may require different dosing. Consult your doctor if the medication isn't relieving the pain sufficiently.

Side Effects

Stomach upset, headache, blurred vision, drowsiness, dizziness, lightheadedness, difficult urination may occur. If any of these effects persist or worsen, inform your doctor. Notify your doctor promptly if you develop: a rapid heart rate, fainting, black stools, hearing loss, easy bruising, dark urine, yellowing eyes, mental confusion, hallucinations. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, breathing trouble. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: kidney disease, liver disease, seizures, prostate or bladder problems, myasthenia gravis, ulcers or intestinal problems, asthma, nasal polyps, bleeding disorders, glaucoma, allergies (especially allergies to aspirin). Because this medication contains aspirin, children and teenagers should not take this drug if they have chickenpox, influenza or undiagnosed illness without first consulting a doctor about Reye's syndrome, a rare but serious illness. Use caution performing tasks requiring alertness if this medication causes you to feel drowsy. Limit alcohol intake. To avoid dizziness and lightheadedness when rising from a seated or lying position, get up slowly. This medicine may cause stomach bleeding. Daily use of alcohol, especially when combined with this medicine, may increase your risk for stomach bleeding. Check with your doctor or pharmacist for more information. This medication is not recommended for use during pregnancy. Consult your doctor before using this medication. This medication is excreted into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all over-the-counter and prescription medication you may use, including: medication for depression or seizures, narcotic pain relievers, sleeping pills or sedatives, "blood thinners" (anticoagulants such as warfarin, heparins, NSAIDs), corticosteroids, methotrexate. Aspirin is an ingredient in many over-the-counter products. To prevent an overdose of aspirin, read the labels carefully before taking other pain relievers or cold products to be sure they do not contain aspirin. Consult your pharmacist if you are uncertain your over-the-counter products contain aspirin. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include drowsiness, sluggishness, loss of muscle coordination, vomiting, stomach pain, rapid breathing, ringing in the ears, and sweating.


This medication is used in addition to rest, physical therapy or other measures prescribed to relieve your condition. Since this medication may make you temporarily feel better, do not try to speed your recovery by exercising or lifting too soon. It may cause further muscle damage. Follow your doctors orders.

Missed Dose

If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat and light. Do not store in the bathroom.