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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(ap-ruh-KLON-eh-deen, off-THAL-mick)



This medication reduces pressure in the eye. It is used to control or prevent elevated eye pressure in patients undergoing certain eye procedures (such as laser treatment).

How To Use

Apply eye drop to the eye as follows: Wash hands first. To avoid contamination, be careful not to touch the dropper tip or let it touch your eye. One drop from the first container is instilled in the eye to be operated upon one hour before laser treatment. A second drop (from the second container) is instilled in the same eye immediately after completion of laser treatment. Discard each container after use. Tilt your head back, gaze upward and pull down the lower eyelid to make a pouch. Place dropper directly over eye and administer the drop. Look downward and gently close your eye for 1 to 2 minutes. Place one finger at the corner of the eye near the nose and apply gentle pressure. This will prevent the medication from draining away from the eye. Try not to blink and do not rub the eye. Wash hands after use.

Side Effects

Raising of upper eyelid, paleness of eye or lining of eyelid, increase in pupil size of eye, inflamed eye, headache, or burning, itching or irritated eyes may occur. If any of these effects continue or become bothersome, inform your doctor. Notify your doctor if you develop: irregular heartbeat, eye pain, changes in vision, stomach upset, dry mouth, sweating, shortness of breath, tingling of the hands or feet. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: other eye problems, high blood pressure, heart disease, allergies (especially to clonidine). Vision may be temporarily blurred or unstable for a few minutes after applying the drops. Use caution if driving or performing duties requiring clear vision. This medication should be used only if clearly needed during pregnancy or while breast-feeding. Discuss the risks and benefits with your doctor.

Drug Interactions

Tell your doctor of all the medications you use (both prescription and nonprescription), especially of: MAO inhibitors (e.g., furazolidone, linezolid, moclobemide, phenelzine, procarbazine, tranylcypromine). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symtoms of overdose may include slow heartbeat, drowsiness, or very cold skin. This medicine may be harmful if swallowed.


This medication is usually given by a health care professional one hour before and at the completion of the eye procedure. Continued therapy is usually not necessary.

Missed Dose

If the scheduled dose is missed, contact your ophthalmologist.


Store at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from heat and light. Discard this if the solution turns color, cloudy or contains particles.