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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(ap-ruh-KLON-eh-deen, off-THAL-mick)



This medication reduces pressure in the eye. It is used in the treatment of glaucoma.

How To Use

This medication is for use in the eye(s) only. It is applied 3 times per day. Use this as directed. Do not apply this more often or continue using this for longer than prescribed. Apply eye drops to the affected eye(s) as follows: Wash hands first. To avoid contamination, be careful not to touch the dropper tip or let it touch your eye. Shake the eye drops well before using. Tilt your head back, gaze upward and pull down the lower eyelid to make a pouch. Place dropper directly over eye and administer the prescribed number of drops. Look downward and gently close your eye for 1 to 2 minutes. Place one finger at the corner of the eye near the nose and apply gentle pressure. This will prevent the medication from draining away from the eye. Try not to blink and do not rub the eye. Do not rinse the dropper. Wash hands after use. If you are using another kind of eye drop, wait at least five minutes before applying other medications.

Side Effects

Raising of upper eyelid, paleness of eye or lining of eyelid, increase in pupil size of eye, inflamed eye, headache; or burning, itching or irritated eyes may occur. If any of these effects continue or become bothersome, inform your doctor. Vision may be temporarily blurred or unstable for a few minutes after applying the drops. Use caution if driving or performing duties requiring clear vision. Notify your doctor if you develop: irregular heartbeat, eye pain, changes in vision, stomach upset, dry mouth, sweating, shortness of breath, tingling of the hands or feet. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: other eye problems, high blood pressure, heart disease, allergies (especially to clonidine). This medication should be used only if clearly needed during pregnancy or while breast-feeding. Discuss the risks and benefits with your doctor.

Drug Interactions

Tell your doctor of all drugs you use (both prescription and nonprescription), especially of: MAO inhibitors (e.g., furazolidone, linezolid, phenelzine, moclobemide, tranylcypromine). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include slow heartbeat, drowsiness, or very cold skin. This medicine may be harmful if swallowed.


Do not share this product with others.

Missed Dose

If you miss a dose, apply it as soon as remembered unless it is nearing the time for your next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not "double-up" on the dose in order to catch up.


Close container tightly after each use. Store at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from heat and light. Do not freeze. Discard this if the solution turns color, cloudy or contains particles.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).