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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Eptifibatide is used to help prevent blood clotting that occurs during certain heart conditions (e.g., acute coronary syndrome) or medical procedures (e.g., percutaneous coronary intervention-PCI). It works by preventing platelets in the blood from sticking to each other. When platelets stick to each other, this can cause blood clots that may lead to medical complications.

How To Use

Follow all instructions for proper mixing and refer to the eptifibatide dosing chart for the recommended IV dosing. If you have questions regarding the use of this medication, consult your pharmacist. Give this medication as an initial dose (bolus dose) into a vein (IV push) followed by an IV infusion as directed by your doctor. The dosage is based on your weight, medical condition and response to therapy. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.

Side Effects

Injection site reactions (e.g., minor bleeding, redness, or discomfort) may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: easy bruising or bleeding, pink or red-colored urine, black stool, coffee-ground vomit, one-sided weakness, vision problems, confusion, slurred speech. If you notice other effects not listed above, contact your doctor or pharmacist.


This medication is not recommended for use if you have the following medical conditions: active bleeding problems, poorly controlled high blood pressure, certain types of stroke (stroke within 30 days or any history of hemorrhagic stroke), major surgery in the past 6 weeks, severe kidney disease (requiring dialysis). Tell your doctor your medical history, especially of: kidney problems, low platelet counts, bleeding problems (e.g., clotting difficulty; any stomach, eye, brain, or lung bleeding), high blood pressure (hypertension), any allergies. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. Use caution and/or limit other injections you may receive while being treated with this drug. Receiving other injections (IV or IM) may increase your risk for bleeding. Tell your doctor if you are pregnant before receiving this medication. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

This drug is not recommended for use with other drugs similar to eptifibatide (other GP 2b3a inhibitors such abciximab). Ask your doctor or pharmacist for more details. Tell your doctor or pharmacist all prescription and nonprescription medication you may use, especially: other "blood thinning" medications (e.g., aspirin, clopidogrel, ticlopidine, dipyridamole, heparin, warfarin, NSAIDs such as ibuprofen, or thrombolytics such as alteplase), furosemide injection. Eptifibatide has been used effectively in combination with other "blood thinners" such as aspirin, clopidogrel, ticlopidine, and anticoagulants such as heparin. Be sure to check with your doctor or pharmacist regarding which medicines you need to take after leaving the hospital. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: trouble breathing, loss of coordination, severe rash and/or bleeding.


Laboratory and/or medical tests (e.g., hematocrit, platelet counts) may be performed to monitor your progress.

Missed Dose

If your dose is stopped or interrupted, contact the doctor immediately to establish a new dosing schedule.


Store in a refrigerator between 36 and 46 degrees F (2 and 8 degrees C) away from light. If necessary, this medication may be stored at room temperature between 59 and 86 degrees F (15 and 30 degrees C) for no longer than 2 months (after removal from refrigerated storage). Discard any unused portion of the vial(s).

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).