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IMURAN
AZATHIOPRINE - INJECTION

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

AZATHIOPRINE - INJECTION

(aze-uh-THIGH-oh-preen)

COMMON BRAND NAME(S): Imuran

WARNING: Long-term use of this medication increases the risk of developing neoplasias (cancerous or noncancerous growths). Azathioprine can also cause blood disorders (e.g., leukopenia). Immediately notify your doctor if you develop unusual growths, easy bruising or bleeding, or signs of infection such as persistent sore throat or fever.

Uses

This medication alters the body's immune system so that your body does not reject a transplanted organ. It is also used to treat severe rheumatoid arthritis after other treatments have failed to provide relief.

How To Use

This drug may be given by vein (IV) until you are able to take the tablet form by mouth. It is usually given once daily. Dosage is adjusted based on your condition and response. Follow all instructions for proper mixing and dilution with certain IV fluids. Consult your pharmacist. This drug product should be checked visually for particles or discoloration before use. If present, do not use the liquid.

Side Effects

Nausea/vomiting, loss of appetite, diarrhea or pain at the injection site may occur. If these effects persist or worsen, notify your doctor promptly. Unlikely but report promptly: hair loss, unusual fatigue, stomach pain, joint or muscle pain, vision changes. Very unlikely but report promptly: yellowing of eyes or skin, darkened urine, unusual bleeding or bruising, lumps/growths. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Tell your doctor your medical history, including: allergies, liver or kidney disease, blood disorders, infections. This medication can lower the body's ability to fight an infection. Notify your doctor promptly if you develop signs of an infection such as fever, chills or persistent sore throat. This drug is not recommended for use during pregnancy. Consult your doctor before using this drug. This drug is excreted into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all nonprescription and prescription medication you use, especially of: allopurinol, drugs affecting bone marrow (e.g., cotrimoxazole, numerous anti-cancer drugs), "alkylating" type cancer drugs (e.g., melphalan, cyclophosphamide, chlorambucil), other immune suppressants (e.g., cyclosporine), "blood thinners" (e.g., warfarin, heparin), ACE inhibitors (e.g., captopril, lisinopril). Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, and diarrhea.

Notes

Do not share this medication with others. Laboratory and/or medical tests may be performed to monitor for side effects or response to treatment.

Missed Dose

If the dose is missed, contact your doctor immediately to establish a new dosing schedule.

Storage

Store at room temperature between 59 and 77 degrees F (15 - 25 degrees C) away from light and moisture. After mixing and dilution in IV fluids (consult your pharmacist for details), this product is stable at room temperature for 24 hours. Discard any unused portion of the vial.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).