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IMURAN
AZATHIOPRINE - ORAL

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

AZATHIOPRINE - ORAL

(aze-uh-THIGH-oh-preen)

COMMON BRAND NAME(S): Imuran

WARNING: Long-term use of this medication increases the risk of developing neoplasias (cancerous or noncancerous growths). Azathioprine can also cause blood disorders (e.g., leukopenia). Immediately notify your doctor if you develop unusual growths, easy bruising or bleeding, or signs of infection such as persistent sore throat or fever.

Uses

Azathioprine is used to prevent rejection of transplanted organs and for cases of severe arthritis that do not respond to other therapies.

OTHER

Uses

This medication may also be used to treat ulcerative colitis and for other purposes as determined by your doctor.

How To Use

Azathioprine tablets should be taken with food or milk to prevent stomach upset. Take this medication exactly as prescribed. Do not stop taking the medication without your doctor's approval.

Side Effects

Nausea/vomiting, loss of appetite or diarrhea may occur. If these effects persist or worsen, notify your doctor promptly. Unlikely but report promptly: hair loss, unusual fatigue, stomach pain, joint or muscle pain, vision changes. Very unlikely but report promptly: yellowing of eyes or skin, darkened urine, unusual bleeding or bruising, unusual lumps or growths. In the unlikely event you have an allergic reaction to this drug, seek medical attention immediately. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Before you take azathioprine, tell your doctor your medical history especially if you have: liver disease, kidney disease, blood disorders, any infection, any allergies. This medication can increase your risk of developing an infection. Notify your doctor at the first sign of a possible infection (fever, persistent sore throat). Azathioprine is not recommended for use during pregnancy. Consult your doctor before using it. This drug is excreted into breast milk. Breast-feeding while using this medication is not recommended. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all drugs you may use, (both prescription and nonprescription), especially of: blood thinners (e.g., warfarin, heparins), allopurinol, drugs affecting bone marrow (e.g., cotrimoxazole, numerous anti-cancer drugs), "alkylating" type cancer drugs (e.g., chlorambucil, melphalan, cyclosporine), ACE inhibitors (e.g., lisinopril). Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, and diarrhea.

Notes

Lab tests will be done frequently while taking this medication to monitor its effects. Do not allow anyone else to take this medication.

Missed Dose

If you take this once daily and miss a dose, take it as soon as remembered but not if it is almost time for the next dose. Skip the missed dose and resume regular schedule. Do not double-up the dose to catch up. If you take this several times daily and miss one dose, take it as soon as you can or double-up the very next dose. If you miss more than one dose, contact your doctor. You may need to have your dosing schedule adjusted.

Storage

Store at room temperature away from moisture and sunlight. Do not store in the bathroom.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).