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GEODON
ZIPRASIDONE - INJECTION

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

ZIPRASIDONE - INJECTION

(zih-PRASS-ih-doan)

COMMON BRAND NAME(S): Geodon

Uses

Ziprasidone for injection is used to treat the acute agitation symptoms of schizophrenia. It works by helping to restore the balance of certain natural chemicals in the brain (neurotransmitters).

How To Use

This medication is given by intramuscular injection (IM) by a healthcare professional. The dose and frequency of use will depend on your condition and response to therapy. Follow all directions for proper mixing. Do not mix with other medications. Consult the pharmacist for details. Before using, check this medication visually for particles or discoloration. If either is present, do not use the liquid. This medication is intended for short-term control of acute agitation symptoms. If you require continuous treatment for your condition, your doctor may switch you to an oral medication.

Side Effects

Drowsiness, nausea, dizziness, headache, or pain at the injection site may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these unlikely but serious side effects occur: muscle stiffness, muscle spasms or twitching, unusual decrease in amount of urine, change in vision. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fainting, irregular or unusually fast heartbeat (especially with fever and increased sweating), seizures, trouble swallowing, uncontrolled movements (especially of the face or tongue). Males - in the unlikely event you experience a painful, prolonged erection, stop using this drug and seek immediate medical attention or permanent problems could occur. This medication may in rare instances increase your blood level of a certain hormone (prolactin). In females, this rare increase in prolactin levels may result in unwanted breast milk production, stopping of your menstrual period, or difficulty in becoming pregnant. In males, this rare effect may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor immediately. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: heart problems (e.g., QTc prolongation, arrhythmias, recent heart attack, heart failure). Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, electrolyte imbalance (e.g., hypokalemia, hypomagnesemia), strokes (cerebrovascular disease), history of low blood pressure (e.g., dehydration, hypovolemia), seizures, swallowing difficulty, Alzheimer's disease, breast cancer, any allergies. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects of the drug, especially the drowsiness and blood pressure-lowering effects. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended.

Drug Interactions

Other drugs besides ziprasidone which may affect the heart rhythm (QTc prolongation in the EKG) include dofetilide, pimozide, quinidine, sotalol, procainamide, and sparfloxacin among others. QTc prolongation can infrequently result in serious, rarely fatal, irregular heartbeats. Consult your doctor or pharmacist for details. Ask for instructions about whether you need to stop any other QTc-prolonging drugs you may be using in order to minimize the risk of this effect. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: azole antifungals (e.g., ketoconazole, itraconazole), anti-Parkinson drugs (e.g., pramipexole, ropinirole), certain blood pressure medications (e.g., beta-blockers such as metoprolol or propranolol, "water pills" or diuretics such as furosemide or hydrochlorothiazide, alpha-blockers such as doxazosin or prazosin). Tell your doctor or pharmacist if you take drugs that cause drowsiness, including: medicine for sleep (e.g., sedatives), tranquilizers, anti-anxiety drugs (e.g., diazepam), narcotic pain relievers (e.g., codeine), other psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), anti-seizure drugs (e.g., carbamazepine), muscle relaxants, antihistamines that cause drowsiness (e.g., diphenhydramine). Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of these products. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include slurring of speech, irregular or unusually fast heartbeat, or fainting.

Notes

Do not share this medication with others. Laboratory and/or medical tests (e.g., electrolytes) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store dry powder vials at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from light and moisture. After mixing the drug, store vials away from light either at room temperature for up to 24 hours or in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C) for up to 7 days. Keep all medicines away from children and pets.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).