Find & Manage Your Patient Assistance Programs
Estimated patient savings $600,000,000.00

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.




WARNING: Tell your doctor you are using this medication before undergoing any procedure involving spinal puncture/anesthesia. Using this medication before these procedures has caused major bruising or bleeding (epidural or spinal hematoma) inside your body. This may leave you paralyzed, maybe permanently. Tell your doctor immediately if you have any of these serious side effects: tingling, weakness, numbness, difficulty urinating or pain. This risk is increased when you use other "blood thinning" medications (e.g., aspirin, clopidogrel, warfarin), NSAIDs (e.g., ibuprofen, naproxen), or when certain medication delivery devices (indwelling epidural catheters) are used. You will be monitored closely while you are on this medication.


This medication is a "blood thinner" (anticoagulant). It is used to help prevent blood clots in persons undergoing surgery.

How To Use

Inject under the skin (subcutaneously), usually 1 to 2 hours before surgery, then once a day for 5 to 10 days after the surgery. According to the Canadian manufacturer, an alternative dosing schedule includes skipping the dose of dalteparin before surgery and beginning treatment 4-8 hours after surgery (if no surgical bleeding problems exist). Do not inject into a muscle (intramuscularly). If you are uncertain how this medication should be used, ask your doctor or pharmacist to explain it to you.

Side Effects

Irritation or pain may occur at the injection site. If these effects become severe, inform your doctor. Notify your doctor if you experience: unusual bleeding or bruising, blood in the urine or stool, fever. If you have had a spinal procedure along with this drug, promptly report: weakness, numbness, pain. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Before taking this, tell your doctor your medical history, especially of: bleeding disorders, ulcers, liver disease, kidney disease, high blood pressure, heart disease, strokes, allergies (especially to heparin or pork). This medication should be used only if clearly needed during pregnancy or while breast-feeding. Discuss the risks and benefits with your doctor.

Drug Interactions

Tell your doctor of any nonprescription or prescription medication you may use, particularly: aspirin, anti-inflammatory pain relievers (e.g., ibuprofen, naproxen), other blood thinners. This medication should not be mixed with or added to any other medication in the same syringe. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include excessive bleeding and bruising.


While using this, be extra careful to avoid injuries as this can cause easy bleeding. Use an electric razor and gently brush your teeth.

Missed Dose

If you miss a dose, use it as soon as remembered; do not use it if it is near the time for the next dose. Instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store this at room temperature between 68 and 77 degrees F (20 and 25 degrees C) away from heat and light. Do not freeze. Properly discard of needles and syringes after use.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).