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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


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This medication is used to treat certain blood clotting conditions (Hemophilia A with Factor VIII inhibitors) in patients who are bleeding or are going to have surgery.

How To Use

Inject this medicine into a vein (IV) as directed by your doctor. The dosage and frequency is based on your medical condition and response to therapy. Follow all instructions for proper mixing with the correct IV fluids. If you have any questions about the mixing or use of this medication, ask your pharmacist. This medication must be used immediately after mixing. If this medication is not completely given within one hour after mixing, it increases the risk of certain side effects (e.g., lowered blood pressure). Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.

Side Effects

Headache, fever, rash, drowsiness, and flushing may occur. If these effects persist or worsen, notify the doctor. Tell the doctor immediately if you notice any of these serious side effects: chills and fever, rash and joint pain (2 weeks after using drug), dizziness, lightheadedness (hypotension). Tell the doctor immediately if you notice any of these unlikely but very serious side effects: loss of appetite, severe nausea and vomiting, stomach pain, irregular pulse, trouble breathing, yellowing of the skin or eyes, dark urine, fever, severe fatigue, chest pain with cough. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: liver disease, any allergies (including latex allergy). This medication is made from blood products and tested for signs of any infection. Although highly unlikely, some risk of infection is possible. This medication is only for use in certain patients with hemophilia (Factor VIII inhibitors). Consult your doctor for more information. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you may use, especially: other drugs to control blood clotting (e.g., aminocaproic acid, tranexamic acid). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include chest pain.


Laboratory and/or medical tests will be performed to monitor your progress.

Missed Dose

The dose and schedule for this medication will be determined by your doctor. If you miss a dose, consult your doctor for a new dose schedule.


Before mixing, store the dry powder and mixing solution in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Once mixed, use immediately. Do not refrigerate for later use.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).