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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(am-FET-uh-meen WITH dex-trow-am-FET-uh-meen)


WARNING: Amphetamine-type medications can be habit-forming. Use only as directed. With prolonged use, drug dependence may occur (i.e., withdrawl symptoms may occur after stopping drug). Consult your doctor or pharmacist for more details.


This combination medication is used to treat Attention Deficit Hyperactivity Disorder (ADHD).



This drug may also be used for weight loss, sleep disorders (e.g., narcolepsy), and depression.

How To Use

Take this medication by mouth usually once daily, first thing in the morning; or as directed by your doctor. Taking this medication later in the day may cause trouble sleeping (insomnia). Do not crush or chew the capsules. Swallow the capsule(s) whole. If you have difficulty swallowing this medication whole, the capsule may be opened and the contents sprinkled into soft food (applesauce or yogurt) and taken as directed. Do not chew the food/medication mixture or make-up a supply in advance. Doing so may destroy the drug and/or increase side effects. The dosage is based on your medical condition and response to therapy. Your doctor may adjust your dose frequently (e.g., weekly) to find the dose that is best for you. Use this medication exactly as prescribed. Do not increase your dose, take it more frequently, or use it for a longer period of time than prescribed because this drug can be habit forming and increase your risk of side effects. Also, if used for an extended period of time, do not suddenly stop using this drug without your doctor's approval. When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well. Your doctor may recommend "drug holidays" where your medication is stopped temporarily and behavior is re-evaluated.

Side Effects

Trouble sleeping, nausea, diarrhea, upset stomach, dizziness, headache, nervousness, loss of appetite, or weight loss may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: vomiting, stomach pain, fever, unusual weakness or tiredness, mental/mood changes. Tell your doctor immediately if any of these unlikely but serious side effects occur: unusually fast heartbeat, blurred vision, uncontrolled muscle movements (e.g., tics, tremors), change in sexual ability or desire, chest pain. If you notice other effects not listed above, contact your doctor or pharmacist.


This medication is not recommended for use if you have the following medical conditions: heart or blood vessel- related diseases (e.g., arteriosclerosis, cardiovascular disease), severe high blood pressure, over-active thyroid (hyperthyroidism), eye problems (e.g., glaucoma), emotional instability, history of drug abuse. Tell your doctor your medical history, especially of: other mental/mood problems (e.g., psychological disorders), growth problems, high blood pressure, uncontrolled muscle movements (e.g., tics, Tourette's syndrome), any allergies. This may make you dizzy and can affect your alertness. Use caution engaging in activities requiring alertness such as driving or using machinery. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breast-feeding while taking this medication is not recommended.

Drug Interactions

Certain medications taken with this product could result in serious, even fatal, drug interactions. Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) during, or within 14 days of taking this medicine. Tell your doctor of all prescription and nonprescription medication you may use, especially: tricyclic antidepressants (e.g., amitriptyline, nortriptyline), blood pressure medicine (e.g., beta-blockers), other stimulant medications (e.g., methylphenidate), meperidine. Certain foods and drugs can affect the amount of acid in your stomach/intestine and increase or decrease (depending on the drug) the absorption of this medicine. Tell your doctor if you take any of these products: fruit juices, ascorbic acid (vitamin C), sodium bicarbonate, ammonium chloride, sodium acid phosphate, anti-ulcer medicine (e.g., H2 blockers such as famotidine and ranitidine, PPIs such as omeprazole and lansoprazole), antacids, methenamine, acetazolamide. Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could increase your heart rate or blood pressure. Ask your pharmacist about the safe use of these products. Avoid drinking large amounts of beverages containing caffeine (e.g., coffee, tea, colas). Caffeine can increase the side effects of this medication. This product can affect the results of certain lab tests (e.g., corticosteroid levels). Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: severe mental/mood changes, confusion, severe or persistent headache, severe restlessness, fast breathing.


Do not share this medication with others. Laboratory and/or medical tests (e.g., blood pressure) may be performed to monitor your progress. If used for ADHD, it is recommended that you attend a total treatment program that includes educational, psychological, and social/behavioral treatments.

Missed Dose

If you miss a dose, use it as soon as you remember in the morning hours. If it is in the afternoon or near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature at 77 degrees F (25 degrees C) in a tightly closed container. Brief storage between 59 and 86 degrees F (15 - 30 degrees C) is permitted. Keep away from light and moisture.